Background : Intraampullary Papillary Tubular Neoplasm (IAPTN) is a rare kind of neoplasm in the region of the papilla, which can develop into ampullary cancer via adenoma-carcinoma sequence. While extensive pancreaticoduodenectomy (PD) was traditionally the standard of care, transduodenal ampullectomy (TDA) is now considered an acceptable and feasible option with a similar prognosis, and lower morbidity and mortality rates. There is very little data available about this tumor and its pathogenesis remains unclear. It is often missed by imaging modalities. It is important to note that imaging alone may not be sufficient to diagnose these lesions. Therefore, a biopsy of the suspected lesion is necessary to confirm the ampullary neoplasm on endoscopic procedures. When endoscopic procedures fail, transduodenal ampullectomy is a preferred option in selected diagnosed cases. Herein, we present a case of an IAPTN successfully managed by transduodenal ampullectomy.

Methods : A case report will be presented. The patient’s data were retrieved and reviewed from our MD Portal, St. Luke’s Medical Center electronic medical record.

Results : NA

Conclusions : TDA is underestimated in the era of endoscopy, which can be performed safely with a high degree of safety and efficacy particularly in benign pathologies of the ampulla. It should be incorporated into clinical treatment algorithms, particularly when endoscopic treatments have been unsuccessful.