Detailed Abstract
[E-poster - Biliary & Pancreas (Biliary Disease/Surgery)]
[EP 215] Development of New Platforms for Predicting Early Recurrence And Survival in Resected Gallbladdercancer
Okjoo LEE 1, Hyun Jeong Jeon JEON 4, So Kyoung YOON 2, Sang Geol KIM 4, Hongbeom KIM 3, Sang Hyun SHIN 3, Jin Seok HEO 3, In Woong HAN 3, So Jeong YOON 3
1 Division of Hepatobiliary-Pancreatic Surgery- Department of Surgery, Soon Chun Hyang University Bucheon Hospital, REPUBLIC OF KOREA, 2 Division of Hepatobiliary-Pancreatic Surgery- Department of Surgery, Soon Chun Hyang University Seoul Hospital, REPUBLIC OF KOREA, 3 Division of Hepatobiliary-Pancreatic Surgery- Department of Surgery, Samsung Medical Center, REPUBLIC OF KOREA, 4 Division of Hepatobiliary-Pancreatic Surgery- Department of Surgery, Kyungpook National University Medical Center, REPUBLIC OF KOREA
Background : Gallbladder cancer (GBC) is a rare and highly aggressive malignancy, with majority of patients suffering disease relapse after surgical resection. Even after extended cholecystectomy, which isoften accompanied by high postoperative morbidity, some patients present with early recurrence. This study aimed to develop platforms for predicting early recurrence of patients with resected GBC
Methods : Clinicopathologic data of patients who underwent curative resection for GBC between 2000 and 2020 were retrospectively reviewed. Early recurrence was defined as recurrence within a year from the day of surgery. Logistic regression analysis was performed to investigate risk factors for early recurrence and survival, and new nomograms were developed using the factors with statistical significance.
Results : A total of 251 patients were included in the development cohort. In a nomogram predicting early recurrence, sex, underlying chronic hepatitis, existence of preoperative symptoms, preoperative CEA, sarcopenic obesity, T stage of tumor, and lymph node metastasis were included. The area under the curve (AUC) was 0.872. For predicting overall survival, 9 variables were included: age, sex, underlying chronic hepatitis, existence of preoperative symptoms, existence of gallbladder stones, preoperative CA 19-9, tumor size, T stage of tumor, and lymph node metastasis. The AUC was 0.843.
Conclusions : We proposed new nomograms for predicting early recurrence and survival in resected GBC using preoperatively measurable parameters. Further study is needed to validate the feasibility of the platforms.
Methods : Clinicopathologic data of patients who underwent curative resection for GBC between 2000 and 2020 were retrospectively reviewed. Early recurrence was defined as recurrence within a year from the day of surgery. Logistic regression analysis was performed to investigate risk factors for early recurrence and survival, and new nomograms were developed using the factors with statistical significance.
Results : A total of 251 patients were included in the development cohort. In a nomogram predicting early recurrence, sex, underlying chronic hepatitis, existence of preoperative symptoms, preoperative CEA, sarcopenic obesity, T stage of tumor, and lymph node metastasis were included. The area under the curve (AUC) was 0.872. For predicting overall survival, 9 variables were included: age, sex, underlying chronic hepatitis, existence of preoperative symptoms, existence of gallbladder stones, preoperative CA 19-9, tumor size, T stage of tumor, and lymph node metastasis. The AUC was 0.843.
Conclusions : We proposed new nomograms for predicting early recurrence and survival in resected GBC using preoperatively measurable parameters. Further study is needed to validate the feasibility of the platforms.
SESSION
E-poster
E-Session 03/21 ALL DAY