Detailed Abstract
[E-poster - Biliary & Pancreas (Biliary Disease/Surgery)]
[EP 181] Surgical Outcomes And Predictive Factors of Perihilar Cholangiocarcinoma: a Single-Institution Experience
Hyun Jeong JEON 1, Sang Geol KIM 1, YOON JIN HWANG 1, HYUNG JUN KWON 2
1 Surgery, Kyungpook National University Medical Center, REPUBLIC OF KOREA, 2 Surgery, Kyungpook National University Hospital, REPUBLIC OF KOREA
Background : Perihilar cholangiocarcinoma (PHC), located in a complex hilar structure, often requires major liver resection, imposing significant physical strain on patients. This study aims to investigate prognostic factors for PHC.
Methods : A retrospective analysis was conducted at Kyungpook National University Chilgok Hospital from January 1, 2011, to December 31, 2020. Survival curves were estimated using the Kaplan-Meier method and prognostic factors were evaluated using multivariate Cox regression models.
Results : Of the 108 patients, Ninety-six patients underwent surgery with curative intent. Major liver resection, including hepatopancreaticoduodenectomy, was performed in 72 (66.7%) patients. Postoperative complications were observed in 50 (46.3%) patients, with Clavien-Dindo classification complications > III in 32 (29.6%) and in-hospital mortality in 4 (3.7%) patients. The 1-, 3-, and 5-year overall survival rates were 71.6%, 42.9%, and 31.5%, respectively. Microvascular invasion, low body mass index (BMI), sarcopenia, and elevated CA19-9 were identified as independent prognostic factors for overall survival (HR=2.158, 95% CI: 1.163-4.005, p=0.015; HR=1.803, 95% CI: 1.028–3.164, p=0.040; HR=2.042, 95% CI: 1.193-3.493, p=0.009; HR=1.804, 95% CI: 1.042–3.122, p=0.035, respectively).
Conclusions : Sarcopenia, low BMI, elevated CA19-9, and microvascular invasion indicate a poor prognosis in PHC. The preoperative assessment of sarcopenia and low BMI is crucial for prognostic evaluation.
Methods : A retrospective analysis was conducted at Kyungpook National University Chilgok Hospital from January 1, 2011, to December 31, 2020. Survival curves were estimated using the Kaplan-Meier method and prognostic factors were evaluated using multivariate Cox regression models.
Results : Of the 108 patients, Ninety-six patients underwent surgery with curative intent. Major liver resection, including hepatopancreaticoduodenectomy, was performed in 72 (66.7%) patients. Postoperative complications were observed in 50 (46.3%) patients, with Clavien-Dindo classification complications > III in 32 (29.6%) and in-hospital mortality in 4 (3.7%) patients. The 1-, 3-, and 5-year overall survival rates were 71.6%, 42.9%, and 31.5%, respectively. Microvascular invasion, low body mass index (BMI), sarcopenia, and elevated CA19-9 were identified as independent prognostic factors for overall survival (HR=2.158, 95% CI: 1.163-4.005, p=0.015; HR=1.803, 95% CI: 1.028–3.164, p=0.040; HR=2.042, 95% CI: 1.193-3.493, p=0.009; HR=1.804, 95% CI: 1.042–3.122, p=0.035, respectively).
Conclusions : Sarcopenia, low BMI, elevated CA19-9, and microvascular invasion indicate a poor prognosis in PHC. The preoperative assessment of sarcopenia and low BMI is crucial for prognostic evaluation.
SESSION
E-poster
E-Session 03/21 ALL DAY