Detailed Abstract
[E-poster - Biliary & Pancreas (Pancreas Disease/Surgery)]
[EP 123] The Impact of Preoperative Muscle Change on the Prognosis of Pancreatic Cancer
Hiroaki FUJI 1, Masaharu TADA 1, Kenjiro IIDA 1, Hideaki SUEOKA 1, Tomohiro OKAMOTO 1, Ami KURIMOTO 1, Takahito HIRAI 1, Daisuke SHIRAI 1, Ikuo NAKAMURA 1, Seiko HIRONO 1
1 Department of Surgery, Hyogo Ｍedical Unviersity, JAPAN
Background : Sarcopenia has been reported to be a poor prognostic factor in Pancreatic Ducatal Adenocarcinoma(PDAC) and the loss of skeletal muscle is closely related to the prognosis. In this study, we investigated the impact of preoperative muscle loss on postoperative prognosis of PDAC.
Methods : During 2013 to 2022, among the pancreatic cancer patients who underwent pancreatoduodenectomy at our department, 97 cases with CT images taken at 2 or more time points before surgery were picked up and the impact of changes in skeletal muscle on prognosis was investigated. The mass of skeletal muscle was represented using the Skeletal Muscle Index (the area of muscle at the third lumbar level divided by the square of the height using CT images.)
Results : The cohort consisted of 52 male and 45 female. The median age was 71 (33-86) years old. Preoperative chemotherapy was performed in 32 cases. The median SMI just before surgery was 41.6 (23.2-59.0) cm2/m2. Next, the ratio of SMI change before surgery was measured and the patients were divided into two groups: a group with SMI decrease of 1% or more (group A; N=57) and less than 1% (group B; N=40). The prognosis was significantly better in the group B (3-year survival rate; 56.7% vs. 41.1% (p=0.03), 3-year recurrence-free survival rate; 42.4% vs. 25.0% (p=0.03).
Conclusions : Decreased skeletal muscle mass before surgery may be a poor prognostic factor for PDAC and the maintain of skeletal muscle during the preoperative period could be important to improve the prognosis.
Methods : During 2013 to 2022, among the pancreatic cancer patients who underwent pancreatoduodenectomy at our department, 97 cases with CT images taken at 2 or more time points before surgery were picked up and the impact of changes in skeletal muscle on prognosis was investigated. The mass of skeletal muscle was represented using the Skeletal Muscle Index (the area of muscle at the third lumbar level divided by the square of the height using CT images.)
Results : The cohort consisted of 52 male and 45 female. The median age was 71 (33-86) years old. Preoperative chemotherapy was performed in 32 cases. The median SMI just before surgery was 41.6 (23.2-59.0) cm2/m2. Next, the ratio of SMI change before surgery was measured and the patients were divided into two groups: a group with SMI decrease of 1% or more (group A; N=57) and less than 1% (group B; N=40). The prognosis was significantly better in the group B (3-year survival rate; 56.7% vs. 41.1% (p=0.03), 3-year recurrence-free survival rate; 42.4% vs. 25.0% (p=0.03).
Conclusions : Decreased skeletal muscle mass before surgery may be a poor prognostic factor for PDAC and the maintain of skeletal muscle during the preoperative period could be important to improve the prognosis.
SESSION
E-poster
E-Session 03/21 ALL DAY