Detailed Abstract
[E-poster - Biliary & Pancreas (Pancreas Disease/Surgery)]
[EP 122] Does Cyst Location Matter in Intraductal Papillary Mucinous Neoplasms of the Pancreas? : a Retrospective Multi Institutional Study
Young Dong YU 1, Sehyeon YU 1, Yoo Jin CHOI 1, Hye Sung JO 1, Jae Sung KANG 2, Sae Byul CHOI 2, Wan Bae KIM 2, Sung Ho KIM 3, Hyung Joon HAN 3, Tae Jin SONG 3, Dong Sik KIM 1
1 HBP Surgery And Liver Transplantation, Korea University Anam Hospita, REPUBLIC OF KOREA, 2 HBP Surgery, Korea University Guro Hospital, REPUBLIC OF KOREA, 3 HBP Surgery, Korea University Ansan Hospital, REPUBLIC OF KOREA
Background : Lesion location in other malignancies, such as colorectal cancer, has been shown to be a relevant prognostic indicator of survival and response to therapy; however, this has not been examined for IPMNs. Also the surgical approach and therefore the postoperative burden to the patient is quite different according the location of the lesion. Therefore, the aim of this study was to investigate the association of IPMN location within the pancreas with risk of cancer.
Methods : We reviewed the medical records of patients who underwent pancreatectomy performed for pancreatic IPMN between 2010 and 2022 from 3 tertiary centers. Clinicopathological variables and perioperative and survival outcomes were evaluated.
Results : Among 225 patients, 119 (52.9%) patients had head/uncinate cysts, while 106 (47.1%) had body/tail cysts. Patients with cysts in the head/uncinate were more often male (58% vs 46.2%), had at least one HRS (53.8% vs 34.9%, p<0.05), and more often harbored high grade dysplasia or invasive cancer (52.9% vs 36.8%, p<0.05). On multivariate analysis, age (odds ratio 1.034, p = 0.036) and cyst location (odds ratio 2.006, p = 0.03) in the head/uncinate remained significantly associated with presence of high grade dysplasia or invasive cancer. Although not statistically significant (p = 0.066), there appeared to be a trend toward decreased survival in patients with cysts of the head or uncinate process.
Conclusions : Head/uncinate cysts are more likely to harbor malignancy compared to those of the body/tail. Cyst location should also be considered part of the decision making process for surveillance vs resection for IPMNs.
Methods : We reviewed the medical records of patients who underwent pancreatectomy performed for pancreatic IPMN between 2010 and 2022 from 3 tertiary centers. Clinicopathological variables and perioperative and survival outcomes were evaluated.
Results : Among 225 patients, 119 (52.9%) patients had head/uncinate cysts, while 106 (47.1%) had body/tail cysts. Patients with cysts in the head/uncinate were more often male (58% vs 46.2%), had at least one HRS (53.8% vs 34.9%, p<0.05), and more often harbored high grade dysplasia or invasive cancer (52.9% vs 36.8%, p<0.05). On multivariate analysis, age (odds ratio 1.034, p = 0.036) and cyst location (odds ratio 2.006, p = 0.03) in the head/uncinate remained significantly associated with presence of high grade dysplasia or invasive cancer. Although not statistically significant (p = 0.066), there appeared to be a trend toward decreased survival in patients with cysts of the head or uncinate process.
Conclusions : Head/uncinate cysts are more likely to harbor malignancy compared to those of the body/tail. Cyst location should also be considered part of the decision making process for surveillance vs resection for IPMNs.
SESSION
E-poster
E-Session 03/21 ALL DAY