Detailed Abstract
[E-poster - Biliary & Pancreas (Pancreas Disease/Surgery)]
[EP 120] Relationship between Positron Emission Tomography/Computed Tomography (PET/CT) Classification And Biologic Behavior of Tumor in Solid Pseudo-papillary Neoplasm of the Pancreas
Hye Yeon YANG 1, Sun Il KIM 2, Young Nyun PARK 2, Chang Moo KANG 3
1 Department of Surgery, Division of Hepatobiliary And Pancreatic Surgery And Liver Transplantation, Ajou University Hospital, REPUBLIC OF KOREA, 2 Department of Pathology, Yonsei Cancer Center, Severance Hospital, REPUBLIC OF KOREA, 3 Department of Surgery, Division of Hepatobiliary And Pancreatic Surgery, Severance Hospital, REPUBLIC OF KOREA
Background : Solid pseudo-papillary neoplasm (SPN) is mostly defined as benign looking behavior. However, it may have an aggressive clinical course in some cases. Several studies to find clinical predictor for aggressive pattern have done. Among these, we investigated clinical correlation between SPN’s biologic behavior and pre-operative PET/CT classification.
Methods : A total of 84 patients diagnosed with SPNs were analyzed retrospectively from October 2000 to November 2020 and additional Ki-67 staining were done. Survival outcomes were analyzed according to PET/CT classification and Ki-67 expression patterns.
Results : Patients in pre-operative PET/CT class III showed the highest mean Ki -67 index value (5.01 2.16) than the other groups (ANOVA, p=0.008). Even though, overall survival (OS) and disease-free survival (DFS) showed no difference depending on pre-operative PET/CT classification (p=0.652 for OS, p=0.405 for DFS), more than half of recurred patients (60%, 6 of 10) were categorized as pre operative PET/CT class III (p=0.239).
Conclusions : Patients with pre-operative PET class III showed relatively high Ki-67 index levels and potential correlation with recurrence during follow-up period. These high proliferative pathologic features may lead poor outcome in case of SPN. This result can provide patients-specific follow-up strategy according to preoperative PET classification and Ki-67 index
Methods : A total of 84 patients diagnosed with SPNs were analyzed retrospectively from October 2000 to November 2020 and additional Ki-67 staining were done. Survival outcomes were analyzed according to PET/CT classification and Ki-67 expression patterns.
Results : Patients in pre-operative PET/CT class III showed the highest mean Ki -67 index value (5.01 2.16) than the other groups (ANOVA, p=0.008). Even though, overall survival (OS) and disease-free survival (DFS) showed no difference depending on pre-operative PET/CT classification (p=0.652 for OS, p=0.405 for DFS), more than half of recurred patients (60%, 6 of 10) were categorized as pre operative PET/CT class III (p=0.239).
Conclusions : Patients with pre-operative PET class III showed relatively high Ki-67 index levels and potential correlation with recurrence during follow-up period. These high proliferative pathologic features may lead poor outcome in case of SPN. This result can provide patients-specific follow-up strategy according to preoperative PET classification and Ki-67 index
SESSION
E-poster
E-Session 03/21 ALL DAY