Detailed Abstract
[E-poster - Biliary & Pancreas (Pancreas Disease/Surgery)]
[EP 118] Role of Retrieved Lymph Nodes in Pancreatic Cancer
HyeJeong JEONG 1, Soo Yeun LIM 1, Hochang CHAE 1, Hyeong Seok KIM 1, So Jeong YOON 1, Sang Hyun SHIN 1, In Woong HAN 1, Jin Seok HEO 1, Hongbeom KIM 1
1 Biliary/pancreatic Surgery, Samsung Medical Center, REPUBLIC OF KOREA
Background : Accurate stating is necessary for pancreatic cancer in determining prognosis and stage-appropriate treatment such as adjuvant therapy. However, the minimum number of lymph nodes for proper staging is not well-defined. We evaluated the number of retrieved lymph nodes and its impact on prognosis
Methods : Medical records of pancreatic cancer patients who underwent surgical resection from 2010 to 2021, at Samsung Medical Center were collected retrospectively. Data were analyzed for optimal cut-off value for disease-free survival and overall survival. Subgroup analysis depending on the surgical methods, presence of lymph node metastasis, and pathologic staging were performed.
Results : A total of 808 patients were included. Median number of resected lymph nodes was 17 (IQR 11-24), mean 20.60 lymph nodes in pancreaticoduodenctomy and mean 14.90 lymph nodes in radical antegrade modular pancreatosplenectomy group. There were 423 patients of node positive group. The cut off value for both overall survival and disease-free survival, positive node count was 4, which correlates to the N2 from pancreatic staging system. Optimal cut off value for disease-free survival was 12 (p=0.039) with median DFS of 9 months in less than or equal to 12 lymph nodes, and 12 months in more than 12 lymph nodes.
Conclusions : Retrieving more than 12 lymph nodes would result in improved disease-free survival.
Methods : Medical records of pancreatic cancer patients who underwent surgical resection from 2010 to 2021, at Samsung Medical Center were collected retrospectively. Data were analyzed for optimal cut-off value for disease-free survival and overall survival. Subgroup analysis depending on the surgical methods, presence of lymph node metastasis, and pathologic staging were performed.
Results : A total of 808 patients were included. Median number of resected lymph nodes was 17 (IQR 11-24), mean 20.60 lymph nodes in pancreaticoduodenctomy and mean 14.90 lymph nodes in radical antegrade modular pancreatosplenectomy group. There were 423 patients of node positive group. The cut off value for both overall survival and disease-free survival, positive node count was 4, which correlates to the N2 from pancreatic staging system. Optimal cut off value for disease-free survival was 12 (p=0.039) with median DFS of 9 months in less than or equal to 12 lymph nodes, and 12 months in more than 12 lymph nodes.
Conclusions : Retrieving more than 12 lymph nodes would result in improved disease-free survival.
SESSION
E-poster
E-Session 03/21 ALL DAY