Background : This study aims to evaluate the effectiveness of simultaneous ipsilateral portal vein and hepatic artery ligation as a method for rapid quantitative liver hypertrophy.

Methods : From January 2010 to December 2023, 48 patients who underwent two-stage hepatectomy, including Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS), were enrolled. The patients were divided into three groups: Right Portal Vein Ligation or Embolization (PVO) group, ALPPS group, and Simultaneous Ipsilateral Portal Vein and Hepatic Artery Ligation (SPALQ) group. Perioperative liver volume and outcomes were retrospectively reviewed.

Results : PVO was performed in 22 patients, ALPPS in 19 patients, and SPALQ in 7 patients. The median interval between the first and second hepatectomies was 30.9 ± 17.41 days for PVO, 29.5 ± 13.04 days for ALPPS, and 12.3 ± 2.25 days for SPALQ (p<0.001). The future liver remnant hypertrophy ratio (FLR/TLV) from the first procedure to the preoperative CT before the second procedure was 37.9 ± 5.85% for PVO, 39.2 ± 6.53% for ALPPS, and 46.1 ± 5.67% for SPALQ (p=0.006).

Conclusions : The SPALQ procedure is safe and feasible, proving effective in facilitating rapid contralateral liver regeneration.