Detailed Abstract
[E-poster - Liver (Liver Disease/Surgery)]
[EP 102] Tumor-related Factors Are More Useful in Predicting Hepatocellular Carcinoma after Liver Transplantation Than Genetic Markers
Jae Do YANG 1, Hee Chul YU 1, Joon Hong PARK 2, Jae Geun LEE 3, Heon Yung GEE 4, Dong Yun KIM 4
1 Surgery, Chonbuk National University Hospital, REPUBLIC OF KOREA, 2 Laboratory Medicine, Chonbuk National University Hospital, REPUBLIC OF KOREA, 3 Transplanstation Surgery, Severance Hospital, REPUBLIC OF KOREA, 4 Phamacology, Severance Hospital, REPUBLIC OF KOREA
Background : Liver transplantation (LT) provides the optimal treatment option for patients with early stage hepatocellular carcinoma (HCC). Despite careful selection of patients, HCC may still recur after LT, which is frequently associated with the dismal prognosis of post-transplant survival. We aimed to identify susceptibility loci by performing the first genome-wide association study (GWAS) of HCC recurrence after LT, along with clinical factors using from the Korean Organ Transplantation Registry (KOTRY).
Methods : We used a discovery cohort of 148 patients with HCC recurrence as study groups and 1427 without HCC recurrence as controls after LT to perform a GWAS. We validated our GWAS findings using new replication cohort consisting of 53 in study groups and 588 in controls. We then used the genotype-tissue expression database to identify expression quantitative trait loci of candidate variants. In addition, the Milan criteria was assessed to estimate the risk factors for HCC recurrence after LT.
Results : Variants at the 1q44 locus and SNV in C1orf100 gene were associated with HCC recurrence after LT at genome-wide thresholds of significance as -7log(p). However, these genetic markers were not reproduced in the replication cohort. On the other hand, under the Milan criteria, were statistically associated with lower HCC recurrence after LT (p < 0.05).
Conclusions : In the limited Korean cohort from KOTRY database, tumor-related factors are more useful in predicting recurrent HCC after LT than genetic markers.
Methods : We used a discovery cohort of 148 patients with HCC recurrence as study groups and 1427 without HCC recurrence as controls after LT to perform a GWAS. We validated our GWAS findings using new replication cohort consisting of 53 in study groups and 588 in controls. We then used the genotype-tissue expression database to identify expression quantitative trait loci of candidate variants. In addition, the Milan criteria was assessed to estimate the risk factors for HCC recurrence after LT.
Results : Variants at the 1q44 locus and SNV in C1orf100 gene were associated with HCC recurrence after LT at genome-wide thresholds of significance as -7log(p). However, these genetic markers were not reproduced in the replication cohort. On the other hand, under the Milan criteria, were statistically associated with lower HCC recurrence after LT (p < 0.05).
Conclusions : In the limited Korean cohort from KOTRY database, tumor-related factors are more useful in predicting recurrent HCC after LT than genetic markers.
SESSION
E-poster
E-Session 03/21 ALL DAY