Detailed Abstract
[E-poster - Liver (Liver Disease/Surgery)]
[EP 087] Impact of Resection Margin Size on Survival Outcomes in Intrahepatic Cholangiocarcinoma: a Retrospective Analysis
Kyeong Deok KIM 1, Jong Man KIM 2, Jinsoo RHU 2, Gyu-Seong CHOI 2, Jin Seok HEO 2, Jae-Won JOH 2
1 Surgery, Inha University Hospital, REPUBLIC OF KOREA, 2 Surgery, Samsung Medical Center, REPUBLIC OF KOREA
Background : The optimal resection margin for intrahepatic cholangiocarcinoma (ICC) remains a topic of significant debate, with varying implications for patient survival and recurrence. This study aims to evaluate the impact of different resection margin lengths on the outcomes of patients with ICC.
Methods : A total of 211 patients undergoing surgery for ICC were retrospectively analyzed. Resection margins were classified as 1 cm or less, more than 1 cm and up to 2 cm, and more than 2cm.
Results : The resection margin was ≤ 1 cm, between 1-2 cm, and > 2 cm in 108 (51.2%), 59 (28.0%), and 44 (20.8%) patients, respectively. The 3-year recurrence-free survival (RFS) was 38.6% in the margin ≤ 1cm group, 43.1% in the margin between 1-2 cm group, and 63.5% in the margin > 2 cm group (p = 0.077). The 3-year overall survival (OS) was 48.6% in the margin ≤ 1cm group, 56.7% in the margin between 1-2 cm group, and 79.3% in the margin > 2 cm group (p = 0.007). A resection margin ≤ 2 cm was an independent risk factor for inferior OS (HR: 2.17; 95% CI: 1.12-4.21; P = 0.022) and RFS (HR: 1.75; 95% CI: 1.00-3.04; P = 0.048).
Conclusions : A resection margin ≤ 2 cm was associated with significantly poorer survival outcomes in patients with ICC. Therefore, we recommend aiming for a resection margin of at least 2 cm during ICC resection to potentially improve survival.
Methods : A total of 211 patients undergoing surgery for ICC were retrospectively analyzed. Resection margins were classified as 1 cm or less, more than 1 cm and up to 2 cm, and more than 2cm.
Results : The resection margin was ≤ 1 cm, between 1-2 cm, and > 2 cm in 108 (51.2%), 59 (28.0%), and 44 (20.8%) patients, respectively. The 3-year recurrence-free survival (RFS) was 38.6% in the margin ≤ 1cm group, 43.1% in the margin between 1-2 cm group, and 63.5% in the margin > 2 cm group (p = 0.077). The 3-year overall survival (OS) was 48.6% in the margin ≤ 1cm group, 56.7% in the margin between 1-2 cm group, and 79.3% in the margin > 2 cm group (p = 0.007). A resection margin ≤ 2 cm was an independent risk factor for inferior OS (HR: 2.17; 95% CI: 1.12-4.21; P = 0.022) and RFS (HR: 1.75; 95% CI: 1.00-3.04; P = 0.048).
Conclusions : A resection margin ≤ 2 cm was associated with significantly poorer survival outcomes in patients with ICC. Therefore, we recommend aiming for a resection margin of at least 2 cm during ICC resection to potentially improve survival.
SESSION
E-poster
E-Session 03/21 ALL DAY