Detailed Abstract
[E-poster - Liver (Liver Disease/Surgery)]
[EP 062] Study on Factors Influencing Liver Regeneration and Functional Recovery Utilizing CT Volumetry Program before and after Hepatectomy in Hepatocellular Carcinoma Patients
Sanghwa Song1
Department of Hepatobiliary and Pancreatic Surgery, Chonnam National University Hwasun Hospital
Background : The aim was to investigate the factors influencing liver regeneration and functional recovery before and after hepatectomy in HCC patients using a CT volumetry program. The study assessed parameters such as liver volume, function, and recovery rate, focusing on predicting liver regeneration capacity post-right hepatectomy (RH) in HCC patients. Additionally, clinical factors predicting liver volume recovery rate (LVRR) after liver surgery were explored in the study.
Methods : A study was conducted on 82 patients who underwent RH due to hepatocellular carcinoma at Chonnam National University Hospital in Hwasun from 2014 to 2020. One week before surgery, various preoperative parameters were investigated, including AST, ALT, ALP, PT/INR, albumin, and platelet count. Additionally, postoperative laboratory findings were examined on days 1, 3, and 5 after surgery. CT volumetry was performed using the Dr. Liver program. CT scans were conducted on the 5th day post-surgery, and remnant liver volume was measured. A follow-up CT was performed one month after the surgery. The study aimed to calculate the regeneration ratio based on these measurements.
Results : The analysis excluded four patients among the 82 individuals who died due to postoperative liver failure. Liver regeneration following RH for HCC showed an average volume increase of 65% at five days post-RH and 82% at one-month post-RH. When dividing patients based on a 65% liver regeneration criterion, preoperative factors associated were identified as albumin levels, PT/INR, and platelet count. Multivariate analysis revealed a significant observation in preoperative PT/INR values.
Conclusions : This study has revealed that preoperative liver function and PT/INR values in HCC patients impact liver regeneration after hepatectomy. These findings can be beneficial in predicting the occurrence of postoperative liver failure in patients expected to have a reduced remnant liver volume following hepatectomy. However, it is crucial to acknowledge the limitations of this study, being a single center study.
Methods : A study was conducted on 82 patients who underwent RH due to hepatocellular carcinoma at Chonnam National University Hospital in Hwasun from 2014 to 2020. One week before surgery, various preoperative parameters were investigated, including AST, ALT, ALP, PT/INR, albumin, and platelet count. Additionally, postoperative laboratory findings were examined on days 1, 3, and 5 after surgery. CT volumetry was performed using the Dr. Liver program. CT scans were conducted on the 5th day post-surgery, and remnant liver volume was measured. A follow-up CT was performed one month after the surgery. The study aimed to calculate the regeneration ratio based on these measurements.
Results : The analysis excluded four patients among the 82 individuals who died due to postoperative liver failure. Liver regeneration following RH for HCC showed an average volume increase of 65% at five days post-RH and 82% at one-month post-RH. When dividing patients based on a 65% liver regeneration criterion, preoperative factors associated were identified as albumin levels, PT/INR, and platelet count. Multivariate analysis revealed a significant observation in preoperative PT/INR values.
Conclusions : This study has revealed that preoperative liver function and PT/INR values in HCC patients impact liver regeneration after hepatectomy. These findings can be beneficial in predicting the occurrence of postoperative liver failure in patients expected to have a reduced remnant liver volume following hepatectomy. However, it is crucial to acknowledge the limitations of this study, being a single center study.
SESSION
E-poster
E-Session 03/21 ALL DAY