Detailed Abstract
[E-poster - Liver (Liver Disease/Surgery)]
[EP 060] MAIN CAUSES OF POSTOPERATIVE ESOPHAGEAL-GASTROINTESTINAL BLEEDING AFTER SURGERY ON THE LIVER AND BILE TRACT
Farukh MAHMADZODA1, Marufjon BOLTUBOEV1, Davlatmurod SADULLOEV2, Akbar MURODOV3, Abdurahmon ASHUROV1, Faridun SAFAROV2
1Department of Hepatobiliary and Pancreatic Surgery, Avicenna Tajik State Medical University, Tajikistan, 2Department of Hepatobiliary and Pancreatic Surgery, Institute of Gastroenterology of the Republic of Tajikistan, Tajikistan, 3Department of Hepatobiliary and Pancreatic Surgery, Scientific Center of Oncology of the Republic of Tajikistan, Tajikistan
Background : To clarify the main, common causes of esophageal-gastrointestinal bleeding (EGIB) after operations on the liver and biliary tract.
Methods : The results of treatment of 58 patients with postoperative EGIB after operations on the liver and biliary tract were analyzed. In 33 (56.9%) cases, complications occurred after surgical interventions on the liver, in 25 (43.1%) - after operations on the biliary tract. Consequently, in 72.7% (n=24) of observations, EGIB occurred after severe and traumatic interventions - extensive liver resections. In 92.0% of cases, operations on the biliary tract were performed against the background of obstructive jaundice.
Results : The cause of postoperative EGIB in 62.1% of cases was acute erosive and ulcerative lesions. After extensive anatomical resections of the liver are performed on days 2-3 of the postoperative period, there is a tendency to increase portal pressure, which is associated with a significant decrease in the volume of liver parenchyma, functioning cells and a decrease in the adaptation of organs to the conditions created after surgery. The state of the main blood flow of the liver after anatomical resection showed an increase in blood flow in the portal vein, mainly due to its expansion. Indicators of lipid peroxidation processes in the mucous membrane of the stomach and duodenum in 31.0% of patients with varying degrees of severity of bleeding from acute erosive and ulcerative lesions showed that the level of diene conjugates in biopsy samples of the gastroduodenal mucosa was 2.2±0.10 units. wholesale pl/ml, and malondialdehyde - 6.1±0.23 nmol/mg.
Conclusions : The development of acute erosive and ulcerative lesions of the esophagus and gastroduodenal mucosa is based on disturbances in visceral blood circulation and microcirculation, confirmed by disruption of organ circulation in critical areas of the stomach and an increase in the content of lipid peroxidation products in the mucous membrane.
Methods : The results of treatment of 58 patients with postoperative EGIB after operations on the liver and biliary tract were analyzed. In 33 (56.9%) cases, complications occurred after surgical interventions on the liver, in 25 (43.1%) - after operations on the biliary tract. Consequently, in 72.7% (n=24) of observations, EGIB occurred after severe and traumatic interventions - extensive liver resections. In 92.0% of cases, operations on the biliary tract were performed against the background of obstructive jaundice.
Results : The cause of postoperative EGIB in 62.1% of cases was acute erosive and ulcerative lesions. After extensive anatomical resections of the liver are performed on days 2-3 of the postoperative period, there is a tendency to increase portal pressure, which is associated with a significant decrease in the volume of liver parenchyma, functioning cells and a decrease in the adaptation of organs to the conditions created after surgery. The state of the main blood flow of the liver after anatomical resection showed an increase in blood flow in the portal vein, mainly due to its expansion. Indicators of lipid peroxidation processes in the mucous membrane of the stomach and duodenum in 31.0% of patients with varying degrees of severity of bleeding from acute erosive and ulcerative lesions showed that the level of diene conjugates in biopsy samples of the gastroduodenal mucosa was 2.2±0.10 units. wholesale pl/ml, and malondialdehyde - 6.1±0.23 nmol/mg.
Conclusions : The development of acute erosive and ulcerative lesions of the esophagus and gastroduodenal mucosa is based on disturbances in visceral blood circulation and microcirculation, confirmed by disruption of organ circulation in critical areas of the stomach and an increase in the content of lipid peroxidation products in the mucous membrane.
SESSION
E-poster
E-Session 03/21 ALL DAY