Detailed Abstract
[E-poster - Liver (Liver Disease/Surgery)]
[EP 040] Laparoscopic minor liver resections for colorectal cancer liver metastases in the Ukrainian state centre
Anton BURLAKA1, Veronika ROZHKOVA1, Vaslonok YAROSLAV1, Andriy BEZNOSENKO1
1Department of Hepatobiliary and Pancreatic Surgery, National Cancer Institute, Ukraine
Background : The aim of the study was to ensure that our results are in line with world standards. This is the study from the lower-middle income country that compares short- and long-term outcomes of LLR and open liver resections (OLR) in patients with colorectal cancer liver metastasis (CRLM).
Methods : We conducted a single-center retrospective analysis of patients with CRLM who received laparoscopic (n=102) and open (n=96) surgical treatment for metastatic liver lesions between 2016 and 2023. The tumor characteristics, intra- and post-operative results, overall survival (OS) and disease-free survival (DFS) rate were analyzed and compared.
Results : The LLR were associated with significantly shorter surgery duration (176 min vs. 295 min, p=0.03). There was no significant difference in the amount of blood loss between the two groups (120 ml vs. 350 ml, p=0.058). Additionally, laparoscopic approach was associated with significantly shorter hospital stay – 5 vs. 9 days, p=0.004. The 90-days rate of major complications (Clavien-Dindo≥3) was lower in LLR group – 5.9% vs. 16.6% (p=0.03). There wasn’t registered mortality in LLR group, in OLR group one patient died due to mesenteric thrombosis. We didn’t find statistically significant difference in OS rate between the two group at 1, 3 and 5 years: 97.3%, 74.7%, 43.4% in OLR group, and 95.1%, 70.3%, 49.5% in LLR group, respectively (p=0.53). DFS at 1, 3 and 5 years: 88.7%, 52.3% and 25.5% in LLR group and 71.9%, 53.1% and 19.3% in OLR group, respectively (p=0.66).
Conclusions : Laparoscopic liver surgery is a safe approach in colorectal cancer liver metastases treatment. It was associated with decrease in major morbidity, shorted surgery duration, and reduced post-operative hospital stay. Minimally invasive liver resections showed similar oncological outcomes to open approach in terms of overall and disease-free survival.
Methods : We conducted a single-center retrospective analysis of patients with CRLM who received laparoscopic (n=102) and open (n=96) surgical treatment for metastatic liver lesions between 2016 and 2023. The tumor characteristics, intra- and post-operative results, overall survival (OS) and disease-free survival (DFS) rate were analyzed and compared.
Results : The LLR were associated with significantly shorter surgery duration (176 min vs. 295 min, p=0.03). There was no significant difference in the amount of blood loss between the two groups (120 ml vs. 350 ml, p=0.058). Additionally, laparoscopic approach was associated with significantly shorter hospital stay – 5 vs. 9 days, p=0.004. The 90-days rate of major complications (Clavien-Dindo≥3) was lower in LLR group – 5.9% vs. 16.6% (p=0.03). There wasn’t registered mortality in LLR group, in OLR group one patient died due to mesenteric thrombosis. We didn’t find statistically significant difference in OS rate between the two group at 1, 3 and 5 years: 97.3%, 74.7%, 43.4% in OLR group, and 95.1%, 70.3%, 49.5% in LLR group, respectively (p=0.53). DFS at 1, 3 and 5 years: 88.7%, 52.3% and 25.5% in LLR group and 71.9%, 53.1% and 19.3% in OLR group, respectively (p=0.66).
Conclusions : Laparoscopic liver surgery is a safe approach in colorectal cancer liver metastases treatment. It was associated with decrease in major morbidity, shorted surgery duration, and reduced post-operative hospital stay. Minimally invasive liver resections showed similar oncological outcomes to open approach in terms of overall and disease-free survival.
SESSION
E-poster
E-Session 03/21 ALL DAY