Detailed Abstract
[E-poster - Liver (Liver Disease/Surgery)]
[EP 030] Long-term Survival Outcomes of Surgical Resection Versus Radiofrequency Ablation for Solitary Hepatocellular Carcinoma Less Than 3cm: a Systematic Review And Meta-Analysis
DoYoung LEE 1, SangHoon KIM 1, ByeongGon NA 1, SungMin KIM 1, Rakkyun OH 1, KiHun KIM 1
1 Liver Transplantation, Asan Medical Center, REPUBLIC OF KOREA
Background : The oncologic outcomes of surgical resection (SR) versus radiofrequency ablation (RFA) in treating early-stage hepatocellular carcinoma (HCC) remains controvisial. The aim of this meta-analysis was to compare the long-term survival outcomes between SR and RFA for patients with solitary HCC less than 3cm.
Methods : Electronic databases were searched from January 2000 to July 2023 for studies comparing long-term outcomes between SR and RFA for treatment of HCC. The long-term outcomes including three-, five-, and eight-year overall survival (OS) and recurrence-free survival (RFS) were abstracted. Individual and pooled hazard ratios (HRs) with 95 % confidence interval of each outcome was analyzed.
Results : Eighteen studies including randomized controlled or matched cohort studies comprising 5294 patients were analysed. In terms of OS, SR group had better three-year OS (HR: 0.66, 95% CI [0.56, 0.79], p<0.001), five-year OS (HR: 0.66, 95% CI [0.57, 0.77], p<0.001), and eight-year OS (HR: 0.71, 95% CI [0.57, 0.88], p=0.002). For RFS, SR group had better three-year RFS (HR: 0.63, 95% CI [0.55, 0.72], p<0.001), five-year RFS (HR: 0.60, 95% CI [0.51, 0.70], p<0.001), and eight-year RFS (HR: 0.67, 95% CI [0.60, 0.75], p<0.001). In subgroup analysis, open surgical resection showed better long-term outcomes than RFA in OS and RFS and it was not clear whether minimally invasive surgery is superior to RFA for solitary HCC less than 3cm.
Conclusions : SR is preferred treatment of solitiray HCC less than 3cm over RFA with a better long-term OS and RFS.
Methods : Electronic databases were searched from January 2000 to July 2023 for studies comparing long-term outcomes between SR and RFA for treatment of HCC. The long-term outcomes including three-, five-, and eight-year overall survival (OS) and recurrence-free survival (RFS) were abstracted. Individual and pooled hazard ratios (HRs) with 95 % confidence interval of each outcome was analyzed.
Results : Eighteen studies including randomized controlled or matched cohort studies comprising 5294 patients were analysed. In terms of OS, SR group had better three-year OS (HR: 0.66, 95% CI [0.56, 0.79], p<0.001), five-year OS (HR: 0.66, 95% CI [0.57, 0.77], p<0.001), and eight-year OS (HR: 0.71, 95% CI [0.57, 0.88], p=0.002). For RFS, SR group had better three-year RFS (HR: 0.63, 95% CI [0.55, 0.72], p<0.001), five-year RFS (HR: 0.60, 95% CI [0.51, 0.70], p<0.001), and eight-year RFS (HR: 0.67, 95% CI [0.60, 0.75], p<0.001). In subgroup analysis, open surgical resection showed better long-term outcomes than RFA in OS and RFS and it was not clear whether minimally invasive surgery is superior to RFA for solitary HCC less than 3cm.
Conclusions : SR is preferred treatment of solitiray HCC less than 3cm over RFA with a better long-term OS and RFS.
SESSION
E-poster
E-Session 03/21 ALL DAY