Detailed Abstract
[E-poster - Liver (Liver Disease/Surgery)]
[EP 019] The Prognostic Effect of Regular Surveillance for Recurrence Following Curative Resection for Hepatocellular Carcinoma: a Large Multicentre Analysis
Lan-Qing YAO 1, Han LIU 2, Yong-Kang DIAO 1, Yi-Fan WU 3, Chao LI 2, Ying-Jian LIANG 4, Yong-Yi ZENG 5, Ming-Da WANG 1, Guo-Yue LV 2, Tian YANG 1
1 Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Navy Medical University), CHINA, 2 Hepatobiliary And Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, CHINA, 3 Hepatobiliary Surgery, The First Affiliated Hospital of Nantong University, CHINA, 4 Hepatobiliary Surgery, The First Affiliated Hospital of Harbin Medical University, CHINA, 5 Hepatobiliary Surgery, Mengchao Hepatobiliary Hospital, CHINA, 6 General Surgery, Ziyang First People’s Hospital, CHINA
Background : Surgical resection, the primary curative treatment for hepatocellular carcinoma (HCC), is often overshadowed by the significant risk of recurrence. This study aimed to evaluate the effect of adherence to regular recurrence surveillance on long-term prognosis among patients undergoing curative resection for HCC.
Methods : This multicentre observational study involved those patients undergoing curative-intent surgical resection for early-stage (BCLC stage 0/A) HCC. They were stratified into two groups: those with adherence to a protocol of regular surveillance (check-ups every 2-3 months for the first two years and every 6 months thereafter), and those without, i.e., receiving irregular/no recurrence surveillance. The overall survival (OS), time-to-recurrence (TTR), and post-recurrence survival (PRS) were compared between the two groups.
Results : Among 1,544 patients, 786 (50.9%) received regular surveillance for recurrence during follow-up. Compared to patients receiving irregular/no recurrence surveillance, patients receiving regular recurrence surveillance presented comparable TTR (median: 61.4 vs. 66.2 months, P=0.161) but better OS (median: 113.4 vs. 94.5 months, P=0.010), as well as better PRS among those patients who recurred (median: 37.9 vs. 16.3 months, P<0.001). Multivariable Cox-regression analyses revealed adherence to regular recurrence surveillance as an independent protective factor for enhanced OS (HR: 0.777; 95% CI: 0.663-0.910; P=0.002) and PRS (HR: 0.523; 95% CI: 0.428-0.638; P<0.001).
Conclusions : Adherence to regular recurrence surveillance significantly improved OS and PRS following surgical resection for HCC. It highlights the crucial role of adherence to regular recurrence surveillance in postoperative HCC management, offering a promising avenue to increase opportunities for subsequent curative treatments and improve long-term survival.
Methods : This multicentre observational study involved those patients undergoing curative-intent surgical resection for early-stage (BCLC stage 0/A) HCC. They were stratified into two groups: those with adherence to a protocol of regular surveillance (check-ups every 2-3 months for the first two years and every 6 months thereafter), and those without, i.e., receiving irregular/no recurrence surveillance. The overall survival (OS), time-to-recurrence (TTR), and post-recurrence survival (PRS) were compared between the two groups.
Results : Among 1,544 patients, 786 (50.9%) received regular surveillance for recurrence during follow-up. Compared to patients receiving irregular/no recurrence surveillance, patients receiving regular recurrence surveillance presented comparable TTR (median: 61.4 vs. 66.2 months, P=0.161) but better OS (median: 113.4 vs. 94.5 months, P=0.010), as well as better PRS among those patients who recurred (median: 37.9 vs. 16.3 months, P<0.001). Multivariable Cox-regression analyses revealed adherence to regular recurrence surveillance as an independent protective factor for enhanced OS (HR: 0.777; 95% CI: 0.663-0.910; P=0.002) and PRS (HR: 0.523; 95% CI: 0.428-0.638; P<0.001).
Conclusions : Adherence to regular recurrence surveillance significantly improved OS and PRS following surgical resection for HCC. It highlights the crucial role of adherence to regular recurrence surveillance in postoperative HCC management, offering a promising avenue to increase opportunities for subsequent curative treatments and improve long-term survival.
SESSION
E-poster
E-Session 03/21 ALL DAY