Background : Intraductal papillary mucinous neoplasms of the liver (IPNB) are a relatively new clinical entity. IPNB has malignant potential harboring a broad histological spectrum, ranging from adenoma to invasive carcinoma. There are very few case reports in the literature about its management and surgical technique.

Methods : We present a 48-year-old male patient who presented with right upper abdominal pain associated with intermittent fever and vomiting without jaundice. Contrast-enhanced CT scan and magnetic resonance showed a complex cystic lesion- 8.9 x 7.7 x 8.4 cm with thin internal septation in segment VII/VIII of the right lobe of the liver. His cyst fluid analysis revealed elevated CEA

Results : Laparoscopic right hepatectomy was performed using the gall bladder handle technique. Gall bladder was used for retraction facilitating various steps such as right inflow dissection, parenchymal transection, and hilar division, while cholecystectomy was performed as a last step. The total operative time was 540 min, and the estimated blood loss was 200 ml. The patient was discharged on postoperative day 4 without any major complications such as bile leak. The final histopathological diagnosis was consistent with mucinous cystic neoplasm. After 6 months of follow-up, the patient was doing well with normal liver function.

Conclusions : IPNB is a rare low-grade biliary lesion that can be a precursor of a poor prognosis invasive carcinoma, hence, surgical resection is warranted. Formal anatomical resection reduces bile leak over non-anatomical resection in case of large lesions