Detailed Abstract
[Poster Presentation 12 - Biliary & Pancreas (Pancreas Disease/Surgery)]
[BP PP 12-S2] Glucose-to-lymphocyte Ratio (GLR) As an Independent Prognostic Factor in Patients with Resected Pancreatic Ductal Adenocarcinoma
Su Hyeong PARK 1, Incheon KANG 2, Seung Soo HONG 1, Ha Yan KIM 3, Ho Kyoung HWANG 1, Chang Moo KANG 1
1 Division of Hepatobiliary And Pancreatic Surgery, Department of Surgery, Severance Hospital, REPUBLIC OF KOREA, 2 Department of Surgery, Bundang CHA, REPUBLIC OF KOREA, 3 Department of Biomedical System Informatics, Severance Hospital, REPUBLIC OF KOREA
Background : In recent studies, systematic inflammatory markers have been demonstrated to be useful preoperative predictors of the progression and prognosis of various cancers, including PDAC. We retrospectively evaluated the usefulness of an elevated glucose-to-lymphocyte ratio (GLR) as a sensitive prognostic biomarker of disease-specific survival in 338 patients who underwent surgical resection of pancreatic ductal adenocarcinoma (PDAC).
Methods : The optimal GLR cutoff value was determined using the method of Contal and O’Quigley. Patient demographic, clinical, and imaging data were analyzed to identify preoperative predictors of long-term survival outcomes.
Results : Elevated GLR correlated significantly with aggressive tumor biologic behaviors, such as a high carbohydrate antigen (CA) 19-9 level (P=0.003) and large tumor size (P=0.011). Multivariate analysis identified 1) GLR >92.72 [hazard ratio (HR)=2.475, P<0.001], 2) CA 19-9 level >145.35 (HR=1.577, P=0.068), and 3) symptoms (P=0.064) as independent pre-dictors of long-term cancer-specific survival. These three risk factors were used to group patients into groups 1 (0 factors), 2 (1–2 factors), and 3 (3 factors), which corresponded to significantly different 5-year overall survival rates (50.2%, 34.6%, and 11.7%, respectively; P<0.001).
Conclusions : An elevated preoperative GLR is associated with aggressive tumor characteristics and is an independent predictor of poor postoperative prognosis in patients with PDAC. Further prospective studies are required to verify these findings.
Methods : The optimal GLR cutoff value was determined using the method of Contal and O’Quigley. Patient demographic, clinical, and imaging data were analyzed to identify preoperative predictors of long-term survival outcomes.
Results : Elevated GLR correlated significantly with aggressive tumor biologic behaviors, such as a high carbohydrate antigen (CA) 19-9 level (P=0.003) and large tumor size (P=0.011). Multivariate analysis identified 1) GLR >92.72 [hazard ratio (HR)=2.475, P<0.001], 2) CA 19-9 level >145.35 (HR=1.577, P=0.068), and 3) symptoms (P=0.064) as independent pre-dictors of long-term cancer-specific survival. These three risk factors were used to group patients into groups 1 (0 factors), 2 (1–2 factors), and 3 (3 factors), which corresponded to significantly different 5-year overall survival rates (50.2%, 34.6%, and 11.7%, respectively; P<0.001).
Conclusions : An elevated preoperative GLR is associated with aggressive tumor characteristics and is an independent predictor of poor postoperative prognosis in patients with PDAC. Further prospective studies are required to verify these findings.
SESSION
Poster Presentation 12
Zone F 3/22/2024 2:50 PM - 3:40 PM