Background : Ambulatory laparoscopic cholecystectomy (LC) is increasingly recognized for its advantages over the inpatient approach, including cost-effectiveness and faster recovery. However, its acceptance is limited by patient concerns regarding safety and the potential for postoperative complications. The study aims to compare the operative and postoperative outcomes of ambulatory LC versus inpatient LC, specifically addressing patient hesitations related to early discharge.

Methods : The retrospective study in single center was performed. Patients who underwent LC were divided into ambulatory or inpatient groups based on ASA classification, age, and the availability of postoperative care. Propensity score matching was utilized to ensure comparability between the groups. Data collection focused on demographic information, perioperative data, and postoperative follow-up results to identify the safety of both approaches. The data was analyzed using Stata BE 18.0.

Results : The study included a cohort of 220 patients undergoing laparoscopic cholecystectomy (LC), of which 48 in each group matched post-propensity score matching. The matched analysis indicated that ambulatory LC patients seem to experience shorter operative times and reduced blood loss but no statistically significant (35 min vs 46 min, p value=0.18 and 8.5 ml vs 23 ml, p-value = 0.14 respectively). There were no significant differences in complication rates or readmission frequencies compared to the inpatient cohort.

Conclusions : Ambulatory LC does not compromise safety or efficacy compared to traditional inpatient procedures. The findings suggest that ambulatory LC could be more widely adopted, with appropriate patient education and selection criteria, to alleviate concerns and increase patient acceptance.