Detailed Abstract
[Poster Presentation 8 - Biliary & Pancreas (Biliary Disease/Surgery)]
[BP PP 8-S4] Changes in Clinical Features And Surgical Outcome of Gallbladder Cancer in Korea over 30 Years: a Korea Tumor Registry System-BiliaryPancreas (KOTUS-BP) Database Analysis
SEUNG EUN LEE 1, YOO SHIN CHOI 1, SUK-WON SUH 1, HEE JOO SOHN 1, SUN-WHE KIM 1
1 DEPARTMENT OF SURGERY, Chung-Ang University Hospital, REPUBLIC OF KOREA
Background : The aim of this study was to investigate the changes of clinical features and surgical outcomes of gallbladder cancer (GBC) in Korea during last 30 years using a Korea Tumor Registry System-BiliaryPancreas (KOTUS-BP) database
Methods : In total, 4179 patients who underwent surgery for primary GBC between 1991 and 2022 were obtained.Patients were divided into 3 time periods: period I (1991 to 1999, n=235), period II (2000 to2009, n=1416) , period III (2010 to 2021, n=2528)
Results : As the period increases, laparoscopic operation (12.4%, 28.5%, 40.1%, p<0.001), extended cholecystectomy (38.2%, 51.1%, 60.1%, p<0.001) and curative resection (68.14%, 85.2%, 88.8%, p<0.001) were performed more frequently. More patients experienced less advanced T stage (T1&2, 52.4%, 71.8%, 78.5%, p<0.001) and N0 stage (26.3%, 39.6%, 47.4%, p<0.001). After a median follow-up period of 42 (range 3–268) months, the 5-year overall survival (39.4%, 56.1%, 67.2% p=0.019) and median disease free survival (months) (15, 63, 88, p<0.001) improved. Recurrence occurred less frequently (42.0%, 35.0%, 23.3%, p<0.001). Systemic recurrence was more common than loco-regional recurrence in all periods. More patients underwent adjuvant treatment (8.3%, 22.1%, 26.8%, p=0.017). In multivariate analysis, poor prognostic factors were higher T stage, presence of lymph node metastasis, and no adjuvant treatment.
Conclusions : Over the past 30 years, the survival rate of GBC has increased remarkably as the number of patients who can undergo curative resection due to early diagnosis of GBC and the number of patients receiving adjuvant therapy have increased.
Methods : In total, 4179 patients who underwent surgery for primary GBC between 1991 and 2022 were obtained.Patients were divided into 3 time periods: period I (1991 to 1999, n=235), period II (2000 to2009, n=1416) , period III (2010 to 2021, n=2528)
Results : As the period increases, laparoscopic operation (12.4%, 28.5%, 40.1%, p<0.001), extended cholecystectomy (38.2%, 51.1%, 60.1%, p<0.001) and curative resection (68.14%, 85.2%, 88.8%, p<0.001) were performed more frequently. More patients experienced less advanced T stage (T1&2, 52.4%, 71.8%, 78.5%, p<0.001) and N0 stage (26.3%, 39.6%, 47.4%, p<0.001). After a median follow-up period of 42 (range 3–268) months, the 5-year overall survival (39.4%, 56.1%, 67.2% p=0.019) and median disease free survival (months) (15, 63, 88, p<0.001) improved. Recurrence occurred less frequently (42.0%, 35.0%, 23.3%, p<0.001). Systemic recurrence was more common than loco-regional recurrence in all periods. More patients underwent adjuvant treatment (8.3%, 22.1%, 26.8%, p=0.017). In multivariate analysis, poor prognostic factors were higher T stage, presence of lymph node metastasis, and no adjuvant treatment.
Conclusions : Over the past 30 years, the survival rate of GBC has increased remarkably as the number of patients who can undergo curative resection due to early diagnosis of GBC and the number of patients receiving adjuvant therapy have increased.
SESSION
Poster Presentation 8
Zone B 3/22/2024 2:50 PM - 3:40 PM