Detailed Abstract
[Poster Presentation 7 - Liver (Liver Disease/Surgery)]
[LV PP 7-S2] Advanced HCC: Results in resection of HCC larger than 10cm in a singlecenter - Western series
Sara OLIVEIRA1, Jorge BALAIA1, Silvia GOMES DA SILVA1, Mafalda SOBRAL1, Sofia CARRELHA1, Vasco RIBEIRO1, Jorge LAMELAS1, Raquel MEGA1, Joao SANTOS COELHO1, Hugo PINTO MARQUES1
1Department of Hepatobiliary and Pancreatic Surgery, Curry Cabral Hospital, Portugal
Background : Liver resection is considered the standard treatment for hepatocellular carcinoma (HCC), however it’s value for advanced HCC (>10cm) remains controversial. We have analyzed, in a single center, the long-term outcome associated with surgical resection in patients with such large tumors.
Methods : We retrospectively analyzed the total of 336 patient´s data who underwent liver resection for HCC between May 18th 2003 and January12th 2023. Patients were divided in two groups according to the tumor size, HCC >10cm and HCC <10cm.
Results : Median follow up was 33 months. From a total of 336 patients, 99 had a tumoral diameter larger than 10cm and 84,8% of these presented as a single nodule. All patients were submitted to a curative intent surgery and a major resection was needed in 37 patients (44%). In the subgroup of HCC >10cm, major morbidity was 7% and mortality was 6%. Overall survival was not different between the two groups (5-year survival rate 68% in large HCC vs 74%) and overall disease-free survival at five years was 43% in advanced HCC vs 52%. Advanced HCC had a recurrence rate of 47% vs 41% in HCC<10cm. From multiple independent variables analyzed, the presence of vascular invasion, cirrhosis and increased total bilirubin predicted worse overall survival (p<0.05). In a multiple variable analysis only the presence of cirrhosis was found to have an impact on survival (p<0.05).
Conclusions : Liver resection for HCC larger than 10cm is a safe and valuable option and we confirmed that it can be associated with a satisfying long-term outcome in experienced centers. It is important to do a proper selection of patients, safe techniques, and a standardized care so that adequate outcomes could be achieved.
Methods : We retrospectively analyzed the total of 336 patient´s data who underwent liver resection for HCC between May 18th 2003 and January12th 2023. Patients were divided in two groups according to the tumor size, HCC >10cm and HCC <10cm.
Results : Median follow up was 33 months. From a total of 336 patients, 99 had a tumoral diameter larger than 10cm and 84,8% of these presented as a single nodule. All patients were submitted to a curative intent surgery and a major resection was needed in 37 patients (44%). In the subgroup of HCC >10cm, major morbidity was 7% and mortality was 6%. Overall survival was not different between the two groups (5-year survival rate 68% in large HCC vs 74%) and overall disease-free survival at five years was 43% in advanced HCC vs 52%. Advanced HCC had a recurrence rate of 47% vs 41% in HCC<10cm. From multiple independent variables analyzed, the presence of vascular invasion, cirrhosis and increased total bilirubin predicted worse overall survival (p<0.05). In a multiple variable analysis only the presence of cirrhosis was found to have an impact on survival (p<0.05).
Conclusions : Liver resection for HCC larger than 10cm is a safe and valuable option and we confirmed that it can be associated with a satisfying long-term outcome in experienced centers. It is important to do a proper selection of patients, safe techniques, and a standardized care so that adequate outcomes could be achieved.
SESSION
Poster Presentation 7
Zone A 3/22/2024 2:50 PM - 3:40 PM