Detailed Abstract
[Poster Presentation 5 - Liver (Liver Disease/Surgery)]
[LV PP 5-S5] Clinical significance of Naples prognostic score in predicting short- and long-term outcomes after surgery for hepatocellular carcinoma patients
Kiyotaka HOSODA1, Akira SHIMIZU1, Koji KUBOTA1, Tsuyoshi NOTAKE1, Noriyuki KITAGAWA1, Hitoshi MASUO1, Tomohiko IKEHARA1, Shiori YAMAZAKI1, Shohei HIRANO1, Yuji SOEJIMA1
1Department of Liver Transplantation and Hepatobiliary Surgery, Shinshu University School of Medicine, Japan
Background : The Naples prognostic score (NPS) is a new inflammation-based prognostic score based on serum albumin, total cholesterol, neutrophil-lymphocyte ratio, and lymphocyte-monocytes ratio. Although the association between the survival and NPS has been reported in various cancers, the impact of NPS on short- and long- term outcomes after surgery for hepatocellular carcinoma (HCC) remains controversial. The aim of this study is to elucidate the potential of NPS on survival and the incidence of postoperative complications after initial hepatectomy for HCC.
Methods : This study enrolled 374 HCC patients undergone initial hepatectomy between 2007 and 2021. The short- and long-term outcomes were analyzed based on the value of NPS. Subgroup analysis for overall survival (OS) was also conducted to explore the predictive value of NPS for distinct populations. Prognostic factors and risk factors for severe postoperative complications were identified using multivariate analyses.
Results : The OS and recurrence free survival (RFS) of the low-NPS group was significantly longer than those of the high-NPS group (OS: p = 0.03, RFS: p = 0.04), and high-NPS was an independent prognostic factor for OS (HR, 1.45; 95% CI, 1.01–2.05; p = 0.04). Subgroup analysis revealed that the predictive value of NPS was significantly superior in the group with single tumor (p = 0.03), tumor diameter 5cm or less (p = 0.04) and stage I or II (p = 0.04). Furthermore, the incidence of CD grade ≥ IIIa postoperative complications was significantly higher in NPS score 2-4 group than that in NPS score 0-1 group (20.9% vs. 11.5%, p = 0.03) and NPS score 2-4 was identified as an independent risk factor for the incidence of CD grade ≥ IIIa postoperative complications (OR, 2.06; 95% CI, 1.01–4.20; p = 0.05).
Conclusions : NPS is an effective predictor for severe postoperative complications and prognosis after hepatectomy for HCC patients.
Methods : This study enrolled 374 HCC patients undergone initial hepatectomy between 2007 and 2021. The short- and long-term outcomes were analyzed based on the value of NPS. Subgroup analysis for overall survival (OS) was also conducted to explore the predictive value of NPS for distinct populations. Prognostic factors and risk factors for severe postoperative complications were identified using multivariate analyses.
Results : The OS and recurrence free survival (RFS) of the low-NPS group was significantly longer than those of the high-NPS group (OS: p = 0.03, RFS: p = 0.04), and high-NPS was an independent prognostic factor for OS (HR, 1.45; 95% CI, 1.01–2.05; p = 0.04). Subgroup analysis revealed that the predictive value of NPS was significantly superior in the group with single tumor (p = 0.03), tumor diameter 5cm or less (p = 0.04) and stage I or II (p = 0.04). Furthermore, the incidence of CD grade ≥ IIIa postoperative complications was significantly higher in NPS score 2-4 group than that in NPS score 0-1 group (20.9% vs. 11.5%, p = 0.03) and NPS score 2-4 was identified as an independent risk factor for the incidence of CD grade ≥ IIIa postoperative complications (OR, 2.06; 95% CI, 1.01–4.20; p = 0.05).
Conclusions : NPS is an effective predictor for severe postoperative complications and prognosis after hepatectomy for HCC patients.
SESSION
Poster Presentation 5
Zone F 3/21/2024 2:50 PM - 3:30 PM