Background : Hilar cholangiocarcinoma is known for its poor prognosis due to the late diagnosis. In order for the long-term survival, curative resection is necessary. However, after surgical resection, the 5-year survival rates vary depending on various literature from 14~48%. The aim of this study is to evaluate the prognostic factors for long term survival in hilar cholangiocarcinoma.

Methods : From January 2000 to December 2020, patients who underwent curative resection for hilar cholangiocarcinoma at Samsung Medical Center were included. Demographics, surgical and oncological outcomes, short term complications, recurrence, pathologic results, and survival were analyzed. Prognostic factors were analyzed with Cox proportional hazard models.

Results : Total 449 patients diagnosed with hilar cholangiocarcinoma who underwent intent-to-treat resection at Samsung Medical Center from 2000 to 2020 were included in this study. The median disease-free survival was 19 months and median survival was 40 months. 1-, 3-, and 5-year survival rates were 82.8%, 53.7%, and 35.8% respectively.

Conclusions : Actual five-year survival of hilar cholangiocarcinoma was 35.8% at Samsung Medical Center. Median survival was 40 months. N2 stage and tumor biology were factors affecting the five-year survival.