Detailed Abstract
[Poster Presentation 1 - Biliary & Pancreas (Pancreas Disease/Surgery)]
[BP PP 1-S5] The Impact of Controlling Nutritional Status (CONUT) Score Changes in Pancreatic Cancer Patients Undergoing Curative Surgery with Neoadjuvant Chemotherapy on Prognosis.
Seul Ah PARK 1, Young Min HAN 1, Mi Rang LEE 1, Young Jae CHO 1, Hye Sol JUNG 1, Won Gun YUN 1, Yoon Soo CHAE 1, Woo Il KWON 1, Jin-young JANG 1
1 Surgery, Seoul National University Hospital, REPUBLIC OF KOREA
Background : As an immune-nutritional marker, the CONUT score has been reported as a prognostic factor in pancreatic cancer. Recent efforts to improve overall survival (OS) in pancreatic cancer patients have led to changes in treatment strategies, with many reports suggesting that neoadjuvant chemotherapy (NAC) can improve OS. However, most prior studies primarily assessed pre-surgery CONUT score. This study aims to investigate the impact of CONUT score changes, determined by immune-nutritional status, between NAC and the preoperative period on pancreatic cancer patient’s prognosis.
Methods : A total 148 pancreatic cancer patients underwent curative surgery following NAC at SNUH between January 2010 and December 2020. Patients were assessed based on their CONUT scores and divided into three groups based on changes in their CONUT score, namely the “Increase”, “Decrease”, and “No-change” groups, after which survival was evaluated.
Results : According to the CONUT score alterations, 93 patients (62.8%) showed no change, 38 patients (25.7%) showed an increase, and 17 patients (11.5%) showed a decrease. The median survival period was significantly shorter in the increased groups compared to the decreased group, even when compared to the no-change group (28 vs. 58 vs. 38 months, p = 0.03). In a multivariate analysis, the increased group (HR; 1.95, 95% confidence interval 1.20.-3.16, p = 0.00) was independently a significant prognostic factor.
Conclusions : Maintaining their initial nutritional status, as determined by the CONUT score, or preventing its deterioration until the preoperative phase emerges as a significant prognostic factor.
Methods : A total 148 pancreatic cancer patients underwent curative surgery following NAC at SNUH between January 2010 and December 2020. Patients were assessed based on their CONUT scores and divided into three groups based on changes in their CONUT score, namely the “Increase”, “Decrease”, and “No-change” groups, after which survival was evaluated.
Results : According to the CONUT score alterations, 93 patients (62.8%) showed no change, 38 patients (25.7%) showed an increase, and 17 patients (11.5%) showed a decrease. The median survival period was significantly shorter in the increased groups compared to the decreased group, even when compared to the no-change group (28 vs. 58 vs. 38 months, p = 0.03). In a multivariate analysis, the increased group (HR; 1.95, 95% confidence interval 1.20.-3.16, p = 0.00) was independently a significant prognostic factor.
Conclusions : Maintaining their initial nutritional status, as determined by the CONUT score, or preventing its deterioration until the preoperative phase emerges as a significant prognostic factor.
SESSION
Poster Presentation 1
Zone A 3/21/2024 2:50 PM - 3:30 PM