Detailed Abstract
[BP Oral Presentation 2 - Biliary & Pancreas (Biliary Disease/Surgery)]
[BP OP 2-S2] Survival Impact of Time Interval of Completion Radical Cholecystectomy in T2 Gallbladder Cancer : Multicenter Study
Soo Yeun LIM 1, HyeJeong JEONG 1, Hochang CHAE 1, Hyeong Seok KIM 1, So Jeong YOON 1, Sang Hyun SHIN 1, In Woong HAN 1, Jin Seok HEO 1, Huisong LEE 2, Jaewoo KWON 3, Hee-Joon KIM 4, Jae-Do YANG 5, Hongbeom KIM 1
1 Division of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Samsung Medical Center, REPUBLIC OF KOREA, 2 Division of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Ewha Womans University Medical Center, REPUBLIC OF KOREA, 3 Division of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Kangbuk Samsung Medical Center, REPUBLIC OF KOREA, 4 Division of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Chonnam National University Hospital, REPUBLIC OF KOREA, 5 Division of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Chonbuk National University Hospital, REPUBLIC OF KOREA
Background : While radical cholecystectomy (RC) is the gold standard for T2 gallbladder cancer (GBC), however, considering the surgical risks and the patients’ comorbidities, strategic approach for simple cholecystectomy (SC) is performed intentionally for both the staging and risk mitigation. Also, the optimal interval of completion radical cholecystectomy (CRC) is debatable, impacting surgical difficulty and oncologic outcomes. This study explores the survival outcome for T2 GBC and optimal interval for CRC.
Methods : Data of 523 patients with T2 GBC who underwent surgery in five tertiary hospital from 2010 to 2019 were analyzed retrospectively.
Results : Of 523 patients, 77(14.7%) patients underwent SC, 104(19.8%) underwent CRC, and 342(65.3%) underwent RC. SC exhibited an older age, a higher rate of laparoscopic procedure, and higher R1 ratio compared to others. Between RC and CRC, RC demonstrated higher T/ N-stage, a greater number of retrieved lymph nodes, and higher adjuvant treatment ratio. Multivariate analysis for disease free survival identified N-stage, operation method, margin status, and complication as independent risk factors, while T-stage did not. RC showed higher survival outcome compared to the patients who received adjuvant treatment after SC, even when classified by N-stage (p=0.011). Within CRC, classification by the interval indicated that there were no statistically differences in complication, estimated blood loss, number of retrieved lymph nodes, nor survival outcome. Moreover, the interval was not an independent risk factor in survival (p=0.255).
Conclusions : RC should be recommended for T2 GBC to reach better survival. The influence of interval on both short- and long-term outcomes following CRC was little.
Methods : Data of 523 patients with T2 GBC who underwent surgery in five tertiary hospital from 2010 to 2019 were analyzed retrospectively.
Results : Of 523 patients, 77(14.7%) patients underwent SC, 104(19.8%) underwent CRC, and 342(65.3%) underwent RC. SC exhibited an older age, a higher rate of laparoscopic procedure, and higher R1 ratio compared to others. Between RC and CRC, RC demonstrated higher T/ N-stage, a greater number of retrieved lymph nodes, and higher adjuvant treatment ratio. Multivariate analysis for disease free survival identified N-stage, operation method, margin status, and complication as independent risk factors, while T-stage did not. RC showed higher survival outcome compared to the patients who received adjuvant treatment after SC, even when classified by N-stage (p=0.011). Within CRC, classification by the interval indicated that there were no statistically differences in complication, estimated blood loss, number of retrieved lymph nodes, nor survival outcome. Moreover, the interval was not an independent risk factor in survival (p=0.255).
Conclusions : RC should be recommended for T2 GBC to reach better survival. The influence of interval on both short- and long-term outcomes following CRC was little.
SESSION
BP Oral Presentation 2
Room C 3/22/2024 4:30 PM - 5:30 PM