Detailed Abstract
[BP Oral Presentation 1 - Biliary & Pancreas (Biliary Disease/Surgery)]
[BP OP 1-S7] Prognostic Impact of Immunohistochemical Expression of MUC in Curatively Resected Ampulla of Vater Cancer
HYUNG IL SEO 1, Byeong Gwan NOH 1, Young Mok PARK 1, Myunghee YOON 1
1 SURGERY, Pusan National University Hospital, REPUBLIC OF KOREA
Background : The Author’s aim to investigate the potential utilization of various mucin immunohistochemiacal stain ( MUC1, MUC2, MUC5AC, and MUC6) as prognostic biomarkers by using tissue microarray (TMA) of patients who underwent curative resection for AoV cancer.
Methods : A retrospective review was done of 68 AoV adenocarcinoma patients who treated with pancreaticoduodencetomy at Pusan National University Hospital between January 2008 and December 2020.
Results : The frequency of MUC staining in AoV cancer is as follows: MUC1 67/68 (98.5%), MUC2 28/68 (41.2%), MUC5AC 32/68 (47.1%), and MUC6 30/68 (44.1%). MUC 1 was expressed in the majority of AoV cancer. MUC 5AC expression was significant of lymph node metastasis. In univariate analyses, T stage, N stage, lymphovascular invasion and MUC 5AC were associated with worse OS. Among these, N stage and MUC5AC were independent prognostic factors for OS based on multivariate analyses. In univariate analyses, worse RFS was associated with T stage, N stage and lymphovascular invasion but these were not associated with RFS in multivariate analysis. Expression of MUC5AC had worse survival than those without expression of MUC5AC.
Conclusions : MUC5AC may be a biomarker associated with OS in AoV cancer and hold significance, indicating a higher likelihood LN metastasis. Therefore, if MUC5AC presentation is observed in preoperative biopsy, a more aggressive LN dissection could be recommended.
Methods : A retrospective review was done of 68 AoV adenocarcinoma patients who treated with pancreaticoduodencetomy at Pusan National University Hospital between January 2008 and December 2020.
Results : The frequency of MUC staining in AoV cancer is as follows: MUC1 67/68 (98.5%), MUC2 28/68 (41.2%), MUC5AC 32/68 (47.1%), and MUC6 30/68 (44.1%). MUC 1 was expressed in the majority of AoV cancer. MUC 5AC expression was significant of lymph node metastasis. In univariate analyses, T stage, N stage, lymphovascular invasion and MUC 5AC were associated with worse OS. Among these, N stage and MUC5AC were independent prognostic factors for OS based on multivariate analyses. In univariate analyses, worse RFS was associated with T stage, N stage and lymphovascular invasion but these were not associated with RFS in multivariate analysis. Expression of MUC5AC had worse survival than those without expression of MUC5AC.
Conclusions : MUC5AC may be a biomarker associated with OS in AoV cancer and hold significance, indicating a higher likelihood LN metastasis. Therefore, if MUC5AC presentation is observed in preoperative biopsy, a more aggressive LN dissection could be recommended.
SESSION
BP Oral Presentation 1
Room B 3/21/2024 3:30 PM - 4:30 PM